عنوان مقاله [English]
نویسندگان [English]چکیده [English]
In the present study, the teratogenic effects of Physalis alkekengi on the development of placentas at 4th and 6th days of pregnancy had been studied.
Material and Methods: Thirty female rats as random divided to 6 groups including control, experimental 1 and experimental 2 groups that each one at the 4th and 6th day of pregnancy received doses 8g/kg body weight and 10g/kg body weight and experimental 3 group that at 6th day pregnancy received dose 12g/kg of Physalis alkekengi fruitandrsquo;s alcoholic extract. All placentas removed from uterus at the 15th day of pregnancy to study according to morphologic and histologic. The present data showed that Physalis alkekengi fruitandrsquo;s alcoholic extract injection intraperitoneal at the 4th and 6th days of pregnant rat caused significant reduction of placentas diameter and weight and volume in experimental groups in comparison with control group and reduction of diameter and weight and volume in experimental 2 group in comparison with control group. Also morphologic studies showed that had been blood corona at the percent out of placentas experimental groups in comparison with control group. In addition tissue Studies showed the significant increase of the hofbauer cells number at placentas experimental groups in comparison with control.Physalis alkekengifruitandrsquo;s alcoholic extract through suppression of cell division and differentiation and function reduction of some of enzymes and hormones, probably can have negative effects on placentas deficiency development and cell differentiation of some cells. According to reported physiological effects of physalins such as physalin F, alcoholic extract teratogenic effects might be related to physalin F. But it is essential to have more quantitative and qualitative researches in order to have conclusive result. Thus it is recommended to pregnant womenfolk than up to researches completion about this medicinal plant have not used this plant in pregnancy period.