عنوان مقاله [English]
نویسندگان [English]چکیده [English]
Introduction: Cerebralischemialeads toneuronaldeath invulnerablesectionsof brain thatisdue tofreeradical productionandoxidative damage. This study aimed to evaluate the effect of 28 days oral administration of grape seed extract (GSE) (100 mg/pkg(on brain oxidative stress indices after permanent bilateral common carotid arteries occlusion (2VO) or ischemia/hypo perfusion in male adult rats. Materials and methods: a number of 30 rats were divided into test and control groups. To make animal model of permanent cerebral hypo perfusion/ischemia, carotid arteries were ligatured upper and lower and cut bilaterally.RatbraintissuetoseparateStriatumandmeasurement ofmalondialdehydewereextracted. Results: results showed that chronic two-vessel occlusion (2VO) hypo perfusion-ischemia increases brain oxidants such as lipid per oxidation (LPO) (pandlt;0.001. (Post ischemic GSE treatment significantlyreducedLPO in striatum) pandlt;0.001(. Conclusion: GSE administration could remove or scavenge oxidants from brain tissue and improve its functionandpossiblybe used asa wayto treatthisdisease.