تاثیر هشت هفته تمرین مقاومتی بر سطوح سرمی آنزیم‌های کبدی AST، ALT و ALP در مردان دارای اضافه وزن مبتلا به بیماری کبد چرب غیرالکلی

نوع مقاله: مقاله پژوهشی

نویسندگان

دانشگاه آزاد اسلامی، واحد علوم و تحقیقات تهران، گروه تربیت بدنی و علوم ورزشی، تهران، ایران

چکیده

تاثیر انواع مختلف تمرینات ورزشی در بیماران مبتلا به کبد چرب غیرالکلی (NAFLD) مشخص نیست. بنابراین، هدف از پژوهش حاضر بررسی تاثیر هشت هفته تمرین مقاومتی بر سطوح سرمی آنزیم­های کبدی شامل AST، ALT و ALP در مردان دارای اضافه وزن مبتلا به NAFLD بود. بدین منظور، 30 مرد دارای اضافه وزن مبتلا به NAFLD با میانگین سنی 5/2 ± 2/40 و وزن 19/3 ± 5/75 به صورت تصادفی در دو گروه کنترل (15 نفر) و تمرین مقاومتی (15 نفر) تقسیم­بندی شدند. آزمودنی­های گروه تمرین به مدت هشت هفته و هفته­ای سه جلسه در برنامه تمرین مقاومتی شرکت کردند. شدت تمرین از 40 درصد 1RM در هفته اول به 70 درصد 1RM در هفته آخر رسید. نمونه­های خونی در انتهای پروتکل پژوهشی جمع­آوری و متغیرهای مورد نظر در سرم اندازه­گیری شدند. یافته­های پژوهش حاضر با نرم افزار SPSS-24 و استفاده از آزمون آنالیز کوواریانس (ANCOVA) تجزیه و تحلیل شد. نتایج نشان داد که سطوح سرمی AST (024/0 =p) و ALT (006/0 =p) در گروه تمرین مقاومتی به صورت معناداری کاهش یافته است، اما تغییرات در سطوح ALP معنادار نبود (096/0 =p). همچنین، نتایج بهبود معنادار نیمرخ لیپیدی را در گروه تمرین کرده نشان داد (001/0 =p). بر اساس نتایج پژوهش حاضر، تاثیرات مثبت تمرینات مقاومتی در بیماران مبتلا به NAFLD ممکن است بواسطه کاهش سطوح آنزیم­های کبدی اعمال شود و این برنامه تمرینی می­تواند نقش موثری در تعدیل نیمرخ لیپیدی بیماران مبتلا به NAFL داشته باشد.

کلیدواژه‌ها


عنوان مقاله [English]

Effect of Eight Weeks Resistance Training on Serum Levels of Hepatic Enzymes Including AST, ALT and ALP in Overweight Mens with Nonalcoholic Fatty Liver Disease

نویسندگان [English]

  • S. Nejadsalim
  • M. Gholami
Department of Exercise Physiology, Science and Research Branch, Islamic Azad University, Tehran, Iran
چکیده [English]

The effect of different types of exercise training in patients with nonalcoholic fatty liver disease (NAFLD) is unclear. Therefore, the aim of present study was to investigate the effect of eight weeks’ resistance training on serum levels of hepatic enzymes' including AST, ALT and ALP in overweight men’s afflicted by NAFLD. For this purpose, 30 overweight men’s afflicted by NAFLD with average age 40.2 ± 2.5 and weight 75.5 ± 3.19 randomly divided in control (n=15) and resistance training (n=15) groups. Subjects in training group take part in resistance training program for eight weeks and three sessions per week. Training intensity increased from 40 percent of 1RM in first week to 70 percent of 1RM in last week. Blood samples collected in the end of research protocol and given variables measured in serum. Present study result analyzed by SPSS-24 software and using analyze covariance (ANCOVA) test. Results indicated that serum levels of AST (p= 0.024) and ALT (p= 0.006) significantly decreased in resistance training group, but changes in serum levels of ALP wasn’t significant (p= 0.096). Moreover, result indicated significant improvement of lipid profile in trained group (p= 0.001). According to present study result, positive effect of resistance training in patient with NAFLD may be exert by decreasing levels of hepatic enzyme and this training program can play effective role in modulating lipid profile in patient with NAFL.

کلیدواژه‌ها [English]

  • Fatty liver
  • Resistance training
  • Hepatic enzyme
  • Steatosis
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