تاثیر مکمل چندگانه رژیم غذایی بر کیفیت پارامترهای اسپرمی

نوع مقاله: مقاله پژوهشی

نویسندگان

1 گروه زیست شناسی، پردیس علوم تحقیقات فارس، دانشگاه آزاد اسلامی، فارس، ایران گروه زیست شناسی، واحد شیراز، دانشگاه آزاد اسلامی، شیراز، ایران

2 پژوهشگاه رویان، پژوهشکده زیست فناوری جهاد دانشگاهی، مرکز تحقیقات پزشکی تولیدمثل، گروه زیست فناوری تولیدمثل، اصفهان، ایران مرکز باروری و ناباروری اصفهان، اصفهان، ایران

3 پژوهشگاه رویان، پژوهشکده زیست فناوری جهاد دانشگاهی، مرکز تحقیقات پزشکی تولیدمثل، گروه زیست فناوری تولیدمثل، اصفهان، ایران

چکیده

استرس اکسیداتیو به عنوان یک ریسک فاکتور برای تولیدمثل در نظر گرفته شده است. مطالعات مختلف نشان داده­اند که سطح بالایی از تولیدات گونه­های فعال اکسیژن (ROS) می­تواند بر روی پروسه اسپرمیوژنزیز و پتانسیل باروری مردان اثر گذار باشد. برای درمان این افراد، درمان آنتی اکسیدانتی پیشنهاد شده است. لذا هدف از این مطالعه ارزیابی اثر یک مکمل چندگانه رژیم غذائیحاوی ویتامین B، زینک و N-استیل سیسنین بر روی پارامترهای اسپرمی در مردان نابارور است. این مطالعه بر روی 30 مرد نابارور مراجعه کننده به مرکز باروری و ناباروری اصفهان انجام شد. پارامترهای اسپرمی مانند تحرک، غلظت و مورفولوژی قبل و بعد از سه ماه درمان با مکمل چندگانه رژیم غذائی(2 قرص در روز: 600 میلی­گرم) مورد ارزیابی قرار گرفتند. نتایج ابن مطالعه بهبود معنی­داری در تحرک و موروفولوژی اسپرم بعد از درمان نسبت به قبل درمان نشان داد (05/0p<). علاوه بر این غلظت اسپرم  بعد از درمان به صورت غیر معنی داری افزایش یافت (05/0p>). با توجه به اینکه، مکمل چندگانه رژیم غذائیشامل تمام ویتامین ها و اجزاء ضروری چرخه یک کربنی است، بنابراین بهبود پارامترهای اسپرم می­تواند از طریق کاهش استرس اکسیداتیو رخ دهد.

کلیدواژه‌ها


عنوان مقاله [English]

Effect of Multiple Dietary Supplements on the Sperm Parameters Quality

نویسندگان [English]

  • F. Bassri 1
  • M.H. Nasr-Esfahani 2
  • M. Forouzanfar 1
  • M. Tavallaee 3
1 Department of Biology, Fars Science and Research Branch, Islamic Azad University, Shiraz, Iran Department of Reproductive Biomedicine Research Center, Royan Institute for Biotechnology, ACECR, Isfahan, Iran
2 Department of Biology, Shiraz Branch, Islamic Azad University, Shiraz, Iran Department of Reproductive Biotechnology, Reproductive Biomedicine Research Center, Royan Institute for Biotechnology, ACECR, Isfahan, Iran
3 Department of Biology, Shiraz Branch, Islamic Azad University, Shiraz, Iran
چکیده [English]

Excessive production of oxidative stress is considered as a risk factor for reproduction. Several studies show that high level of reactive oxygen species (ROS) can affect spermatogenesis process and fertility potential in men. For treatment of these individuals, antioxidant therapy is suggested. Therefore, the aim of this study was to evaluate the effect of a multiple micronutrient supplement that contains vitamins B, Zinc and N-acetylcysteine on sperm parameters in infertile men. This study was performed on 30 infertile men referred to the Isfahan Fertility and Infertility Center. Semen parameters (concentration, motility, and morphology) were assessed before and after three month of treatment with supplement (2 tablets per day; 600mg). The result of this study showed a significant improvement in sperm motility and morphology (p<0.05) after compared to before treatment. In addition, sperm concentration insignificantly increased after treatment with supplement (p>0.05). Considering multiple micronutrient supplement is containing all of the B vitamins and essential component of One-Carbone cycle, therefore improvement of sperm parameters can be observed due to improved antioxidant capacity and reduced oxidative stress.

کلیدواژه‌ها [English]

  • ROS
  • Multiple micronutrient supplement
  • One -carbon cycle
  • Sperm parameters
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