نوع مقاله : مقاله پژوهشی
نویسندگان
1 دانشجوی دکتری بیوتکنولوژی پزشکی، دانشگاه علوم پزشکی ایران، تهران، ایران
2 مرکز تحقیقات سلولی و مولکولی، دانشگاه علوم پزشکی یاسوج، یاسوج، ایران
3 دکتری حرفه ای دامپزشکی، دانشگاه آزاد اسلامی واحد کرج، کرج، ایران.
چکیده
کلیدواژهها
عنوان مقاله [English]
نویسندگان [English]
Diabetes mellitus can occur due to insulin deficiency or environmental tissues resistance to insulin with the reduction of insulin secretion. The present study aimed to investigate the therapeutic effect of amniotic mesenchymal stem cell transplantation in the treatment of type 1 diabetes. This study was of experimental type and the animals were divided into four groups including the control or healthy, the diabetic control group, the group receiving cells with the medium, and the group receiving only supernatant soup. Glucose and blood insulin levels and animal weight were studied by ANOVA and t-test during the study. With the first stage of stem cell transplantation, a significant reduction was found in the animal blood glucose of both groups receiving cell and medium (p = 0.004) and the group receiving supernatant soup (p = 0.014) than the control group. Such results were not observed after the second stage. The insulin levels had no statistically significant difference. The present study indicated that the repeated transplantation of Amniotic Mesenchymal stem cells can decrease the blood glucose but increase the blood insulin level and the injection of supernatant soup alone be solely effective as much as the cell transplantation.
کلیدواژهها [English]
Aali E., 2014. A comparative study of mesenchymal stem cell transplantation with its paracrine effect on control of hyperglycemia in type 1 diabetic rats. Journal of Diabetes & Metabolic Disorders, 13(1): 76-85.
2. Bassi E.J., 2012. Immune regulatory properties of allogeneic adipose-derived mesenchymal stem cells in the treatment of experimental autoimmune diabetes. Journal of Diabetes, 61(10): 2534- 2545.
Zanone M.M., 2010. Human mesenchymal stem cells modulate cellular immune response to islet antigen glutamic acid decarboxylase in type 1 diabetes. The Journal of Clinical Endocrinology Metabolism, 95(8): 3788-3797.