تأثیر هشت هفته تمرین هوازی- مقاومتی بر بیان ژن LXR و سطح سرمی TNFα در بیماران CABG

نوع مقاله: مقاله پژوهشی

نویسندگان

1 گروه تربیت بدنی و علوم ورزشی، واحد نیشابور، دانشگاه آزاد اسلامی، نیشابور، ایران

2 گروه بیوشیمی و متابولیسم ورزشی، دانشکده تربیت بدنی و علوم ورزشی، دانشگاه فردوسی مشهد، ایران

3 گروه تربیت بدنی و علوم ورزشی، واحد مشهد، دانشگاه آزاد اسلامی، مشهد، ایران

4 گروه علوم و صنایع غذایی، واحد نیشابور، دانشگاه آزاد اسلامی، نیشابور، ایران

چکیده

ب
بیماری­های قلبی عروقی به عنوان یکی از اصلی­ترین علت­های مرگ و میر در دنیا شناخته شده­اند. بر اساس اعلام انجمن قلب آمریکا، گسترش بیماری­های قلبی عروقی زمینه ی التهابی دارد و التهاب عمومی، نقش محوری در ایجاد آتروسکروز دارد. هدف از این پژوهش بررسی تأثیر هشت هفته تمرین هوازی - مقاومتی  بر بیان ژن LXR و سطح سرمی TNFα در بیماران  CABG بود. 24 نفر از مردانی که تحت عمل جراحی بای پس قرار گرفته بودند به طور داوطلبانه انتخاب و به صورت تصادفی به دو گروه تجربی (12 نفر) و کنترل (12 نفر) تقسیم شدند. گروه تجربی به مدت هشت هفته تمرینات مقاومتی- هوازی را انجام دادند (3 جلسه در هفته) و گروه کنترل در این مدت بدون تمرین بودند. نمونه گیری خونی 48 ساعت قبل از شروع اولین جلسه تمرینی و همچنین 48 ساعت پس از آخرین جلسه تمرینی  در حالی که همه آزمودنی‌ها ناشتا بودند به عمل آمد. برای تحلیل داده­ها از آزمون آماری تی- استودنت مستقل و همبسته و آزمون شاپیروویلک جهت نرمال کردن داده­ها در سطح معنی داری 05/0 استفاده شد. نتایج پژوهش حاضرنشان داد گروه تمرین در نتیجه­ی هشت هفته تمرینات مقاومتی- هوازی افزایش معنی داری را در بیان MRNA ژن LXR و کاهش در سطح سرمی TNFα در مقایسه با گروه کنترل تجربه کردند. همین تغییرات نیز به صورت درون گروهی در گروه تمرین به صورت پیش آزمون و پس آزمون دیده شد. یافته های این پژوهش نشان داد که هشت هفته برنامه تمرینی ترکیبی هوازی- مقاومتی  به صورت منظم می­تواند باعث افزایش بیان ژن LXR و کاهش سطح سرمی TNFα در بیماران CABG شود.

کلیدواژه‌ها


عنوان مقاله [English]

The Effect of Eight Weeks of Aerobic Resistance Training on LXR Gene Expression and Serum TNFα Levels in CABG Patients

نویسندگان [English]

  • Fahimeh Parhizi 1
  • Amir Rashidlamir 2
  • Rambod khajei 1
  • Mohammd Reza Ramzanpour 3
  • Mohsen Vazifehdoost 4
1 Department of Physical Education and Sport Sciences, Islamic Azad University, Neyshabour Branch, Neyshabour, Iran
2 Associate Professor, Ph.D. in Biochemistry and Exercise Metabolism, Faculty of Physical Education and Sport Sciences, Ferdowsi University of Mashhad, Mashhad, Iran
3 Associate Professor, Department of Exercise Biochemistry and Metabolism, Faculty of Physical Education and Sport Sciences, Islamic Azad University of Mashhad, Mashhad, Iran
4 Department of Food Science and Industries, Islamic Azad University, Neyshabour Branch, Neyshabour, Iran
چکیده [English]

Cardiovascular diseases are one of the leading causes of death in the world. According to the American Heart Association, the prevalence of the cardiovascular diseases has an inflammatory basis, and general inflammation plays a central role in the development of atherosclerosis. The purpose of this study was to investigate the effect of eight weeks of aerobic resistance training on LXR gene expression and serum TNFα levels in CABG patients. Twenty-four men who underwent bypass surgery were voluntarily selected and randomly divided into experimental (n=12) and control (n=12) groups. The experimental group performed aerobic resistance training for eight weeks (3 sessions per week) and the control group did not. Blood samples were taken 48 hours before the start of the first training session and also 48 hours after the last training session while all subjects fated. Independent and paired samples Student's t-test and Shapirovilk test were used to normalize the data at a significant level of 0.05. The results of the present study showed that the training group experienced a significant increase in LXR mRNA gene expression and a decrease in serum TNFα levels as a result of eight weeks of aerobic resistance training compared to the control group. The same changes were seen as the within group differences in the pre-test and post-test in the training group. The findings of this study showed that an eight-week combined aerobic and resistance training program could regularly increase the LXR gene expression and decrease serum TNFα levels in CABG patients

کلیدواژه‌ها [English]

  • Aerobic resistance training
  • Cardiac rehabilitation
  • LXR
  • TNFα
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