بررسی تاثیرکوآنزیم Q10 بر فعالیت های باروری، افسردگی و اضطراب در موش های نر

نوع مقاله: مقاله پژوهشی

نویسندگان

1 گروه زیست شناسی، واحد تهران شمال، دانشگاه آزاد اسلامی، تهران، ایران

2 گروه زیست‌شناسی، واحد گوهردشت کرج، دانشگاه آزاد اسلامی، کرج، ایران

چکیده

کوآنزیم Q10 یک ترکیب بنزوکینون محلول در چربی آندروژن است که در بیشتر بافت­های بدن یافت می‌شود. کوآنزیم Q10 خاصیت آنتی­اکسیدانی قوی دارد و خنثی‌کننده رادیکال‌های آزاد است. هدف از این تحقیق بررسی تاثیرکوآنزیم Q10 به عنوان یک آنتی­اکسیدانت قوی و خنثی‌کننده رادیکال‌های آزاد بر اختلالات تولیدمثل، رفتارهای جنسی، اضطراب و افسردگی در موش نر است. در این تحقیق از موش­های کوچک نر با محدوده وزنی 35-30 گرم استفاده شد. ابتدا حیوانات مورد آزمایش یک دوره تیمار دو هفته­ای را گذراندند. به مدت دو هفته موش­های نر بالغ با دوزهای 200، 300 و 400 میلی­گرم بر کیلوگرم کوآنزیم Q10 تیمار شدند. سپس اثرات تیمار مورد نظر در بخش­های فیزیولوژیکی مورد مطالعه و بررسی قرار گرفتند. پس از پایان دوره تیمار، رفتارهای جنسی در موش­های گروه کنترل و گروه­های تیمار شده به وسیله تست رفتار جنسی ارزیابی شد. سپس سطوح اضطراب و افسردگی در موش­های نر بالغ به ترتیب به وسیله دستگاه (EPM) و تست شنای اجباری ارزیابی شد. یافته‌های حاصل از این مطالعه نشان دادند که تجویز کوآنزیم Q10 به تنهایی اثر معنی­داری بر رفتارهای جنسی، افسردگی و اضطراب موش  نر نداشت.

کلیدواژه‌ها


عنوان مقاله [English]

Evaluating the Effect of Coenzyme Q10 (CoQ10) on Fertility, Depression, and Anxiety in Male Rats

نویسندگان [English]

  • Maryam Sharafi chie 1
  • Ramin Hajikhani 1
  • Jalal Solati 2
  • Maryam khosravi 1
1 1- Department of Biology, North Tehran Branch, Islamic Azad University, Tehran, Iran
2 2- Department of Biology, Gohardasht Branch, Islamic Azad University, Karaj, Iran
چکیده [English]

Quenzim Q10 (CoQ10) is a benzoquinone compound soluble in androgen lipid found in most tissues of the body. CoQ10 has a potent antioxidant activity and neutralizes free radicals. The aim of this study was to investigate the effect of CoQ10 as a potent antioxidant and free radicals neutralizer on reproductive disorders, sexual behaviors, anxiety, and depression in male rats. In this study, small male rats (weight range of30-35 g) were used. At first, the animals under study passed a two-week treatment period. The adult male rats were treated with doses of 200, 300, 400 mg/kg of CoQ10 for two weeks. Then the effects of the given treatment were studied in the physiologic section. After the end of the treatment period, the sexual behaviors were assessed in the control group and treated groups by sexual behavior test. Then, the anxiety and depression levels in adult male rats were assessed using EPM and forced swimming tests, respectively. The findings of this study showed that the prescription of CoQ10 alone did not have a significant effect on sexual behaviors, depression, and anxiety in male rats.

کلیدواژه‌ها [English]

  • Quenzim Q10 (CoQ10)
  • Free radical
  • Oxidative stress
  • Fertility
  • Depression
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