تاثیر هشت هفته تمرین هوازی و مقاومتی بر غلظت های سرمی عامل رشد عصب و نوروتروفین 4 در زنان مبتلا به نوروپاتی دیابتی

نوع مقاله: مقاله پژوهشی

نویسندگان

1 گروه فیزیولوژی ورزشی، دانشکده علوم ورزشی، دانشگاه بیرجند، بیرجند، ایران

2 گروه فیزیولوژی ورزشی، دانشکده علوم ورزشی، دانشگاه فردوسی مشهد، مشهد، ایران

3 گروه علوم پایه، دانشکده پزشکی، دانشگاه علوم پزشکی نیشابور، نیشابور، ایران

چکیده

ن
نوروپاتی دیابت اختلال اعصاب محیطی در افراد مبتلا به دیابت است که تارهای عصبی در این بیماران را تحت تاثیر قرار می­دهد. هدف از پژوهش حاضر بررسی تاثیر هشت هفته تمرین هوازی و مقاومتی بر غلظت­های سرمی عامل رشد عصب و نوروتروفین 4 در زنان مبتلا به نوروپاتی دیابتی بود. تعداد 45 زن دیابتی با میانگین سنی 58/4±  97/47 سال بصورت نمونه در دسترس انتخاب شدند. سپس آنها بصورت تصادفی به سه گروه 15 نفری کنترل، تمرین هوازی و تمرین مقاومتی تقسیم شدند. سطوح NGF و NT4قبل و بعد از دوره تمرینی تهیه و به روش الایزا ساندویچ اندازه­گیری شد. برنامه تمرین برای مدت هشت هفته با تواتر سه جلسه و شدت 50 تا 70 درصد ضربان قلب ذخیره انجام گرفت. همچنین برنامه تمرین مقاومتی برای هشت هفته و تواتر سه جلسه و نیز شدت 40 تا 60 درصد یک تکرار بیشینه دنبال شد. از آزمون آماری اندازه­های تکراری برای تجزیه و تحلیل داده­ها استفاده شد. نتایج افزایش معنی داری در سطوح سرمی NGF در هر دو گروه تمرین هوازی (001/0 = p) و مقاومتی (001/0 = p) پس از هشت هفته مقایسه گردید که این تغییرات نسبت به گروه کنترل معنی دار نبود (05/0≥ p) و نسبت به همدیگر معنی­دار نبود (50/0= p). همچنین افزایش معنی داری در سطوح سرمیNT4 در هر دو گروه تمرین هوازی (015/0 = p) و مقاومتی (153/0 = p) پس از هشت هفته مقایسه گردید که این تغییرات نسبت به گروه کنترل معنی­دار بود اما نسبت به همدیگر معنی­دار نبود (00/1 = p). بنظر می­رسد که تمرین مقاومتی و هوازی اثر محافظتی روی افزایش پیشرفت بیماری نوروپاتی دیابتی دارد و حتی می­تواند پیشرفت این بیماری را کند یا بهبود دهد.

کلیدواژه‌ها


عنوان مقاله [English]

The Effect of Eight Weeks of Aerobic and Resistance Training on Serum Concentrations of Nerve Growth Factor and Neurotrophin 4 in Women with Diabetic Neuropathy

نویسندگان [English]

  • Farideh Rezaee namjoo 1
  • Mahdi Mogharnasi 1
  • Amir Rashid Lamir 2
  • Saeid Samarghandian 3
1 Department of Sport Physiology, Faculty of Sport Sciences, Birjand University, Birjand, Iran
2 Department of Sport Physiology,Faculty of Sport Sciences, Ferdowsi University, Mashhad, Iran
3 Department of Basic Sciences, Faculty of Medicine, Neyshabur University of Medical Sciences, Neyshabur, Iran
چکیده [English]

Diabetic neuropathy is a peripheral nerve disorder in people with diabetes that affects the nerve fibers in these patients. This study has been perforemd aiming to investigate the effect of eight weeks of aerobic and resistance training on serum concentrations of nerve growth factor and neurotrophin 4 in women with diabetic neuropathy. Forty-two diabetic women with the avergae age of 47.97 ±4.58 years were selecetd by convenience sampling. Then, they were randomly divided into three groups including the control, aerobic and resistance training groups (15 people in each group). NGF and NT4 levels were measured by sandwitch ELISA before and after training . The training program was done for eight weeks (three sessions a week) with 50-70% of heart rate reserve. Resistance training was also continued for eight weeks and three sessions a week with an intensity of 40-60% of a maximum repetition. Repeated measures ANOVA test was used for data analysis. The results of the significant increase in serum NGF levels were compared in aerobic (p=0.001) and resistance (p=0.001) groups after eight weeks; the changes were not significant compared to the control group (p≤0.05) and in comparison of the two mentioend groups (P=0.50).Also, significance of the increase in serum NT4 levels was comapred in aerobic (p=0.015) and resistance (p=0.153) groups after eight weeks; the changes in the groups were significant compared to control group, but not comaprd to each other (p=1.00). Aerobic resistance training seems to have a protective effect on progression of diabetic neuropathy, and it can even slow or improve the progression of the disease.

کلیدواژه‌ها [English]

  • Diabetic Neuropathy
  • Neuronal Growth Factor
  • Neurotrophin-4
  • Aerobic training
  • Resistance training
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