بررسی اثرات عصاره آبی گیاه شاهی Lepidium sativum بر روی رفتارهای شبه اضطرابی و شبه افسردگی در موش های سوری نر بالغ

نوع مقاله : مقاله پژوهشی

نویسندگان

1 گروه زیست شناسی، واحد تهران شمال، دانشگاه آزاد اسلامی، تهران، ایران

2 گروه زیست شناسی، واحد گوهر دشت کرج، دانشگاه آزاد اسلامی، کرج، ایران

3 گروه ژنتیک، واحد علوم پزشکی، دانشگاه آزاد اسلامی، تهران، ایران

چکیده

اضطراب و افسردگی از شایعترین بیماری­های روانی هستند. استرس اکسیداتیو از جمله  عوامل ایجاد اضطراب و افسردگی است. دانه شاهی دارای خواص ضد التهابی، آنتی اکسیدانی می­باشد. هدف از این تحقیق بررسی اثر عصاره آبی گیاه شاهی بر رفتارهای شبه اضطرابی و شبه افسردگی در موش های سوری نر بالغ است. در این تحقیق از موش های کوچک نر با محدوده وزنی 35-30 گرم استفاده شد. ابتدا حیوانات مورد آزمایش به مدت 2 هفته تحت تیمار با عصاره آبی دانه شاهی با دوز های   200 ،400 و 600 میلی­گرم بر کیلوگرم قرار گرفتند. پس از پایان دوره تیمار، سطوح اضطراب و افسردگی به ترتیب به وسیله دستگاه ماز بعلاوه مرتفع (EPM) و تست شنای اجباری ارزیابی شد. در هیچ یک از گروه­های دریافت کننده عصاره شاهی تغییرات معنی داری در زمان سپری شده در بازوی باز ، تعداد ورود به بازوی باز و فعالیت حرکتی مشاهده نشد. نتایج حاصل از تست شنای اجباری نشان داد که  در حیوانات دریافت کننده عصاره شاهی با  دوزهای 400 و 600 میلی­گرم بر کیلوگرم  زمان شنا و زمان بی حرکتی نسبت به گروه کنترل به ترتیب افزایش  و کاهش معنی داری  داشته است (01/0 p <). یافته های حاصل از این مطالعه اثرات تعدیل کنندگی عصاره دانه شاهی بر رفتارهای شبه افسردگی را نشان داد، اما  این عصاره بر رفتارهای شبه اضطرابی اثرات معنی داری  نداشت.

کلیدواژه‌ها


عنوان مقاله [English]

Evaluation of the Effects of Aqueous Extract of Cress (Lepidium sativum) on Anxiety-like and Depression-like Behaviors in Adult Male Mice

نویسندگان [English]

  • Fatemeh Rahimiasl 1
  • Maryam Khosravi 1
  • Ramin Hajikhani 1
  • Jalal Solati 2
  • Hossien Fahimi 3
1 Department of Biology, North Tehran Branch, Islamic Azad University, Tehran, Iran
2 Department of Biology, Karaj Branch, Islamic Azad University, Karaj, Iran
3 3- Department of Genetics, Medical Sciences Branch, Islamic Azad University, Tehran, Iran
چکیده [English]

Anxiety and depression are the most common mental illnesses. Oxidative stress is one of the causes of anxiety and depression. Lepidium sativum has anti-inflammatory and antioxidant properties. The aim of this study was to investigate the effect of aqueous extract of Lepidium sativum on anxiety-like and depression-like behaviors in adult male mice. In this study, male mice weighing 30-35 g were used. First, the tested animals were treated with aqueous extract of Lepidium sativum at doses of 200, 400 and 600 mg/kg for 2 weeks. At the end of the treatment period, the levels of anxiety and depression were assessed by an elevated plus maze (EPM) and forced swimming test, respectively. No significant changes were observed in any of the groups receiving Lepidium sativum extract in the time spent in the open arm, the number of entrances to the open arm and motor activity. The results of forced swimming test showed that in animals receiving Lepidium sativum extract at doses of 400 and 600 mg/kg, swimming time and immobility time were significantly increased and decreased compared to the control group, respectively (p < 0.01). The results of this study showed the modulatory effects of Lepidium sativum extract on depressive-like behaviors, but this extract had no significant effects on anxiety-like behaviors.

کلیدواژه‌ها [English]

  • Depression
  • anxiety
  • Lepidium sativum
  • Mice
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