تأثیر یک دوره تمرین هوازی-مقاومتی بر بیان ژن گیرنده‌ی فعال‌کننده پرولیفراسیون پروگسیزوم گاما بیماران بای‌پس عروق کرونری

نوع مقاله : مقاله پژوهشی

نویسندگان

1 گروه تربیت ‌بدنی و علوم ورزشی، واحد نیشابور، دانشگاه آزاد اسلامی، نیشابور، ایران

2 گروه بیوشیمی و متابولیسم ورزشی، دانشکده علوم ورزشی, دانشگاه فردوسی مشهد، مشهد، ایران

چکیده

گیرنده­های فعال­کننده­ی پرولیفراسیون پروگسیزوم گاما فاکتوری یک عامل رونویسی فعال‌شده به­وسیله لیگاند می­باشد که نقش مهمی در متابولیسم لیپیدها دارد. هدف از پژوهش حاضر اثر هشت هفته تمرینات هوازی-­مقاومتی بر بیان ژن گیرنده­­ی فعال­کننده­ پرولیفراسیون پروگسیزوم گاما در بیماران بای­پس عروق گرونری  بود. روش پژوهش­حاضرنیمه­تجربی و با طرح پیش­آزمون-پس­آزمون بود. جامعه آماری­ کلیه بیماران بای­پس عروق­ کرونری شهر مشهد بودند.در مطالعه حاضر نمونه پژوهشی شامل 26 مرد میان‌سال  با دامنه سنی 75/3 ± 73/56 (سال)، قد 03/0 ± 58/1 (متر)، وزن 54/5 ± 11/68 (کیلوگرم)،  شاخص توده بدن 47/2 ± 18/27 (کیلوگرم/مترمربع) و سابقه­ی بیماری 75/8 ± 20/25 (ماه) پس از عمل بای­پس عروق کرونر تشکیل‌شده بود. بر اساس معیارهای ورود به تحقیق، در دو گروه در تجربی (14) و کنترل (12) قرار گرفتند. داده­ها با استفاده از آزمون تی­مستقل وتی­همبسته در ­سطح معنی­داری 05/0≥p  و نرم­افزار SPSS نسخه 21تحلیل شدند. نتایج نشان داد که هشت هفته تمرینات هوازی-مقاومتی سبب افزایش بیان ژن PPAR در گروه تمرین ترکیبی نسبت به گروه کنترل شد (001/0=p ). همچنین نتایج آماری آزمون تی­همبسته نشان داد که افزایش بیان ژن PPAR در گروه تمرین ترکیبی افزایش معناداری در پس‌آزمون نسبت به پیش­آزمون داشت (001/0=p ) که این افزایش در گروه کنترل معنی­دار نبود (081/0=p ). داده­های پژوهش حاضر نشان داد تمرینات هوازی-مقاومتی با افزایش بیان ژن PPAR می­تواند در متابولیسم چربی­ها و فرآیند­های وابسته به آن در بیماران بای­پس عروق کرونری تأثیرگذار باشد.

کلیدواژه‌ها

عنوان مقاله [English]

The Effect of a Course of Aerobic-resistance Training and Ursolic Acid Consumption on Irisin Levels and Inflammatory Factors in Overweight Middle-aged Men

نویسندگان [English]

  • Amin Aahedi Anaraki 1
  • Rambod Khajei 1
  • Amir Rashid lamir 2
  • Amene Barjasteh yazdi 1
1 Department of Physical Education, Neyshabur Branch, Islamic Azad University, Neyshabur, Iran
2 Department of Sport Biochemistry and Metabolism, Faculty of Sport Sciences, Ferdowsi University of Mashhad, Mashhad, Iran
چکیده [English]

Gamma-factor progesterone proliferation activating receptors are a ligand-activated transcription factor playing an important role in lipid metabolism. The present study was aimed at evaluating the effect of eight weeks of aerobic-resistance training on the expression of gamma progesterone proliferator-activating receptor gene in patients with coronary artery bypass grafting. The research method was quasi-experimental and pre-test-post-test. The statistical population included all patients with coronary artery bypass grafting in Mashhad (Iran). Height 1.58 ± 0.03 (m), weight 68.11 ± 5.54 (kg), body mass index (BMI) 27.18 ± 2.47 (2 kg / m2) and disease history 75 8.75 ± 25/20 (month) were formed after coronary artery bypass surgery. According to the inclusion criteria, they were divided into experimental (14) and control (12) groups. Data were analyzed using independent t-test and paired t-test at the significance level of P≥0.05 and SPSS software version 21. The results showed that eight weeks of aerobic-resistance training increased the expression of PPARɣ gene in the combined training group compared to the control group (P = 0.001). Moreover, the results of the correlation test showed that the increase in PPAR gene expression in the combined training group had a significant increase in the post-test compared to the pre-test (P = 0.001), not significant in the control group (p = 0.081). The data of the present study showed that aerobic- resistance training with increasing PPARɣ gene expression could be effective in fat metabolism and related processes in patients with coronary artery bypass grafting.

کلیدواژه‌ها [English]

  • Aerobic
  • Resistance Exercises
  • PPARɣ
  • CABG

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فصلنامه زیست شناسی جانوری
دوره 14، شماره 1
پاییز 1400
صفحه 81-91

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