بررسی اثر یک دوره بازتوانی قلبی مبتنی بر تمرین ترکیبی بر بیان ژن VEGF در بیماران قلبی با سابقه عمل جراحی بای پس کرونری

نوع مقاله : مقاله پژوهشی

نویسندگان

1 گروه تربیت‌بدنی و علوم ورزشی، واحد نیشابور، دانشگاه آزاد اسلامی، نیشابور، ایران

2 گروه تربیت‌بدنی و علوم ورزشی، دانشکده تربیت‌بدنی و علوم ورزشی، دانشگاه فردوسی مشهد، مشهد، ایران

چکیده

بیماری‌های قلبی­عروقی از علل اصلی مرگ ‌و میر در تمام کشورهای جهان به‌جز قاره افریقا است. هدف از پژوهش حاضر بررسی تأثیر هشت هفته تمرین ترکیبی بر بیان ژن‌های اندوستاتین و VEGF بیماران CABG بود. این پژوهش از نوع تحقیقات کاربردی و به روش نیمه تجربی با دو گروه (مداخله و کنترل) است که به صورت پیش آزمون و پس آزمون اجرا شد. تعداد 30 نفر مرد میان‌سال CABG شده به‌صورت نمونه هدفمند و بر اساس معیارهای ورود به پژوهش انتخاب شدند و به‌صورت تصادفی به دو گروه 15 نفری کنترل و تمرین ترکیبی تقسیم شدند. برنامه تمرین ترکیبی برای مدت هشت هفته با تواتر سه جلسه انجام شد. برای اندازه‌گیری سطوح بیان ژن‌های اندوستاتین و VEGF از روش Real time-PCR انجام شد. از آزمون t وابسته و مستقل برای تجزیه‌ و تحلیل داده‌ها استفاده گردید. تمرین ترکیبی به‌طور معنی‌دار بیان ژن VEGF را افزایش داد (001/0≥ p). اما این تغییرات در مورد بیان ژن اندوستاتین (38/0p =  ) معنادار نیست. بررسی نتایج این پژوهش نشان می‌دهد یک دوره تمرین ترکیبی بازتوانی قلب با پروتکل مورداستفاده در پژوهش حاضر، توانست بر شاخص بیان ژن VEGF تغییر معناداری ایجاد کند. اما تمرین ترکیبی نتوانست بر بیان ژن اندوستاتین تأثیرگذار باشد. بنابراین می‌توان بیان کرد که افزایش ژن VEGF از نتایج سازگاری با فعالیت ورزش ترکیبی مورد استفاده در این پژوهش بوده، و به‌احتمال‌زیاد فعالیت بدنی یک عامل مهم و اثرگذار در فرایند آنژیوژنز محسوب می‌شود و می‌تواند نقش مهمی در پیشگیری از مشکلات قلبی داشته باشد

کلیدواژه‌ها


عنوان مقاله [English]

Investigating The Effect of Cardiac Rebalitation Program Based on Combined Training on VEGF Gene Expression in ACS Patients with CABG

نویسندگان [English]

  • Seyed Emad Alavinia 1
  • Amir Rashidlamir 2
  • Rambod Khajei 1
  • Amene Barjasteh Yazdi 1
1 Department of Exercise Physiology, Neyshabur Branch, Islamic Azad University, Neyshabur, Iran
2 Associated Professor, Faculty of Sport Sciences, Ferdowsi University of Mashhad, Iran
چکیده [English]

Cardiovascular diseases are the leading causes of mortality and death in all areas of the world except Africa. This study aimed at the effect of eight-week combined training on Endostatin and VEGF gene expression in CABG patients.This is an applied and semi-experimental research with two groups (interventional and control), which was conducted as a pretest and posttest. 30 middle-aged CABG men were selected using purposive sampling based on inclusion criteria. Participants were randomly divided into two groups of control and combined training. Quantitative Real-time PCR was utilized  to measure Endostatin and VEGF gene expression levels. The eight-week combined exercise training was conducted in three sessions per a week. Dependent t-test and independent t-test were used to data analysis. A significant increase was observed after eight weeks of combined training on VEGF gene expression in CABG  patients. (p=0.001), but it was not Significant on Endostatin gene expression( p=0.38) . Eight weeks of combined  Cardiac Rehabilitation training as the protocol used in  this research increased the expression of the VEGF gene in CABG patients , but there were not any significant changes on Endostatin gene expression by this way. As a result, the increase in the VEGF gene is one of the results of adaptation to the combined exercise activity used in this study, and it appears that physical activity is an important and effective factor in the process of angiogenesis, and can play a key role in the prevention of cardiovascular diseases.

کلیدواژه‌ها [English]

  • Combined training
  • VEGF
  • Gene expression
  • CABG.CR
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