تاثیر پودر زردچوبه بر روی بافت شناسی و وضعیت پاداکسندگی کبد بلدرچین های ژاپنی در معرض کادمیوم خوراکی

نوع مقاله : مقاله پژوهشی

نویسنده

بخش تحقیقات بیماری‌های ویروسی دام، موسسه تحقیقات واکسن و سرم سازی رازی، سازمان تحقیقات، آموزش و ترویج کشاورزی، کرج، ایران

چکیده

آلودگی جیره طیور به کادمیوم علاوه بر خسارت­های اقتصادی ناشی از کاهش تولید، از نظر بهداشت عمومی نیز اهمیت دارد. هدف از انجام این مطالعه، بررسی اثر پودر زردچوبه حاوی میزان مشخصی از کورکومینوئیدها (96/2 درصد) در تعدیل وضعیت پاداکسندگی و ضایعات بافت­شناسی کبد بلدرچین­های ژاپنی در معرض کادمیوم خورکی بود. تعداد 180 قطعه بلدرچین ژاپنی نر از سن 22 تا 55 روزگی به شش گروه با جیره­ای شامل جیره پایه، جیره پایه بعلاوه 3 گرم در کیلوگرم پودر زردچوبه، جیره پایه بعلاوه 5 گرم در کیلوگرم پودر زردچوبه، جیره پایه بعلاوه  100 میلی­گرم در کیلوگرم کادمیوم،  جیره پایه بعلاوه 100 میلی گرم در کیلوگرم کادمیوم و 3 گرم در کیلوگرم پودر زردچوبه و جیره پایه بعلاوه 100 میلی­گرم در کیلوگرم کادمیوم و 5 گرم در کیلوگرم پودر زردچوبه تقسیم شدند. جیره آلوده به کادمیوم، بطور معنی­داری باعث افزایش غلظت مالون دی آلدهید و کاهش فعالیت سوپر اکسید دسموتاز، کاتالاز و ظرفیت پاداکسندگی تام در بافت کبد شد (05/0 > p). تغییرات بافت شناسی کبد، ناشی از تغذیه با جیره آلوده به کادمیوم، شامل تغییر چربی،نکروز انفرادی یاخته های کبدی ، پرخونی و ارتشاح لکوسیتی بود. افزودن پودر زردچوبه به جیره آلوده به کادمیوم، باعث بهبود وضعیت پاداکسندگی کبد و کاهش شدت ضایعات بافت­شناسی کبد گردید (05/0 > p). اضافه کردن 5 گرم پودر زردچوبه به هر کیلوگرم از جیره آلوده به کادمیوم، تأثیر بیشتری در کاهش اثرات نامطلوب کادمیوم در بلدرچین ژاپنی داشت (05/0 > p).

کلیدواژه‌ها


عنوان مقاله [English]

The Effect of Turmeric Powder on the Histology and Antioxidant Status of Japanese Quail liver Exposed to Oral Cadmium

نویسنده [English]

  • Omid Karimi
Department of Animal Viral Diseases Research, Razi Vaccine and Serum Research Institute, Agricultural Research, Education and Extension Organization, Karaj, Iran.
چکیده [English]

Poultry diet contamination with cadmium (Cd) is both important in terms of economic losses due to reduced production and public health. This study aimed to evaluate the effect of turmeric powder (TP) containing a certain amount of curcuminoids (2.96%) on Japanese quail exposed to dietary cadmium. 180 male Japanese quail from 22 to 55 days of age were divided into 6 groups and received, basal diet(BD),  BD + 3 g/kg TP,  BD + 5 g/kg TP,  BD + 100mg/kg Cd, BD + 100 mg/kg  Cd and 3 g/kg TP, and BD + 100mg/kg Cd and 5 g/kg TP. Cadmium contaminated diet significantly decreases SOD, CAT, and total antioxidant capacity and increasing MDA concentration in liver tissue. Cadmium induced hepatic histological lesions, including fatty change, hyperaemia, single hepatocyte necrosis, and leukocyte infiltration. Turmeric powder substantially increased antioxidant status and decreased the severity of liver histological lesions in a cadmium-contaminated diet (P <0.5). When 5 g/kg of turmeric powder was added to the cadmium-contaminated food, the deleterious effects of dietary cadmium in Japanese quail were reduced more effectively.

کلیدواژه‌ها [English]

  • Japanese quail
  • liver
  • Curcuminoides
  • Cadmium
  • Histopathology
  • Antioxidant
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